Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

• Published in: Genome Biology Vol. 21; no. 1; p. 216
• Main Authors: Sa, Jason K., Chang, Nakho, Lee, Hye Won, Cho, Hee Jin, Ceccarelli, Michele, Cerulo, Luigi, Yin, Jinlong, Kim, Sung Soo, Caruso, Francesca P., Lee, Mijeong, Kim, Donggeon, Oh, Young Taek, Lee, Yeri, Her, Nam-Gu, Min, Byeongkwi, Kim, Hye-Jin, Jeong, Da Eun, Kim, Hye-Mi, Kim, Hyunho, Chung, Seok, Woo, Hyun Goo, Lee, Jeongwu, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Kim, Jinho, Park, Woong-Yang, Wang, Qianghu, Sulman, Erik P., Heimberger, Amy B., Lim, Michael, Park, Jong Bae, Iavarone, Antonio, Verhaak, Roel G. W., Nam, Do-Hyun
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.08.2020; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; blood; Brain cancer; Brain tumors; Collagen; Gene expression; gene expression regulation; genes; Genomics; Glioblastoma; Glioma; Glioma cells; immunosuppression; Immunotherapy; irradiation; Macrophages; Malignancy; MARCO protein; Medical prognosis; Mesenchyme; Metastases; Neurofibromin 1; pathogenesis; Peripheral blood; phenotype; Phenotypes; phenotypic plasticity; prognosis; Radiation; Rapamycin; Recruitment; Stem cells; Survival analysis; TOR protein; Transcription; transcription (genetics); Treatment resistance; Tumors
• ISSN: 1474-760X; 1474-7596; 1474-760X
• DOI: 10.1186/s13059-020-02140-x

Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with treatment resistance, unfavorable prognosis, an...