Genetic regions affecting the replication and pathogenicity of dengue virus type 2

• Published in: PLOS Neglected Tropical Diseases Vol. 18; no. 1; p. e0011885
• Main Authors: Samune, Yoshihiro, Saito, Akatsuki, Sasaki, Tadahiro, Koketsu, Ritsuko, Srimark, Narinee, Phadungsombat, Juthamas, Yokoyama, Masaru, Kotani, Osamu, Sato, Hironori, Yamanaka, Atsushi, Haga, Saori, Okamoto, Toru, Kurosu, Takeshi, Nakayama, Emi E., Shioda, Tatsuo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 08.01.2024; Public Library of Science
• Subjects: Analysis; Aquatic insects; Arctic medicine. Tropical medicine; Assaying; Biological response modifiers; Clinical isolates; Cloning; Cytomegalovirus; Dengue; Dengue fever; Dengue hemorrhagic fever; Dengue viruses; Disease transmission; DNA polymerase; DNA sequencing; Epidemics; Gene expression; Gene sequencing; Genetic aspects; Genomes; Genomics; Genotypes; Human diseases; Infections; Infectious diseases; Infectivity; Nucleotide sequencing; Pathogenicity; Pathogens; Plasmids; Prevention; Proteins; Public aspects of medicine; RA1-1270; RC955-962; Replication; Reporter gene; Research Article; Risk factors; Serotypes; Signs and symptoms; Structural proteins; Vector-borne diseases; Viral diseases; Viral replication; Viruses; Whole genome sequencing; Thailand

Dengue is a mosquito-borne disease that has spread to over 100 countries. Its symptoms vary from the relatively mild acute febrile illness called dengue fever to the much more severe dengue shock syndrome. Dengue is caused by dengue virus (DENV), which belongs to the Flavivirus genus of the family F...