Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis

• Published in: Applied microbiology and biotechnology Vol. 96; no. 3; pp. 739 - 748
• Main Authors: Yeh, Hsu-Hua, Chiang, Yi-Ming, Entwistle, Ruth, Ahuja, Manmeet, Lee, Kuan-Han, Bruno, Kenneth S., Wu, Tung-Kung, Oakley, Berl R., Wang, Clay C. C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.11.2012; Springer; Springer Nature B.V
• Subjects: alcohol dehydrogenase; Alcohol Dehydrogenase - genetics; Analysis; Applied Genetics and Molecular Biotechnology; Aspergillus nidulans; Aspergillus nidulans - enzymology; Aspergillus nidulans - genetics; Aspergillus nidulans - metabolism; Aspergillus niger; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Dehydrogenases; DNA sequencing; enzymology; Fungi; Gene Expression Regulation, Fungal; Genes; genetic techniques and protocols; genetics; Genomes; Genomics; Life Sciences; Ligases; Metabolic Engineering; Metabolism; Metabolites; Microbial Genetics and Genomics; Microbiology; multigene family; nucleotide sequences; Nucleotide sequencing; Organisms; Peptide Synthases; Peptide Synthases - genetics; Peptide Synthases - metabolism; Peptides; Pharmacy; Plant metabolites; Polyketides; Polyketides - metabolism; Promoter Regions, Genetic; Science; Secondary metabolites; Studies; Biosynthesis; Nonribosomal peptide synthetase-like; Microperfuranone

Genome sequencing of Aspergillus species including Aspergillus nidulans has revealed that there are far more secondary metabolite biosynthetic gene clusters than secondary metabolites isolated from these organisms. This implies that these organisms can produce additional secondary metabolites, which...