Regioselective reactions for programmable resveratrol oligomer synthesis

• Published in: Nature (London) Vol. 474; no. 7352; pp. 461 - 466
• Main Authors: Snyder, Scott A., Gollner, Andreas, Chiriac, Maria I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.06.2011; Nature Publishing Group
• Subjects: 639/638/403/934; 639/638/549; Biochemistry; Biological Products - biosynthesis; Biological Products - chemical synthesis; Biological Products - chemistry; Bromine - chemistry; Cardiovascular diseases; Chemical properties; Chemical reactions; Chemical reactivity; Chemical research; Chemical synthesis; Chemistry; Chemistry, Pharmaceutical - methods; Diets; Exact sciences and technology; Flavonoids - chemistry; Halogenation; Health aspects; Heart diseases; Humanities and Social Sciences; Indicators and Reagents - chemistry; Isomerism; Mass spectrometry; Materials selection; Methods; multidisciplinary; Natural products; Noncondensed benzenic compounds; Observations; Oligomers; Organic chemistry; Phenols - chemistry; Polycyclic Compounds - chemistry; Polyphenols; Preparations and properties; Production processes; Reactivity and mechanisms; Resveratrol; Science; Science (multidisciplinary); Stilbenes - chemical synthesis; Stilbenes - chemistry; Stilbenes - metabolism; Structure; Substrate Specificity; Synthesis; Terpenes - chemistry; United States; Heart; Chemical reagent; Regioselectivity; Biosynthesis; Selectivity; Natural compound; Saturated fat; Oligomer; Biological activity; Stilbene derivatives; Plant; Polyphenol; Functionalization; Phytoalexin; Heart disease; Plant origin; Resveratrol; Phenols; Benzenic compound; Chemical reactivity; Chemical synthesis

Although much attention has been devoted to resveratrol, a unique polyphenol produced by plants and credited as potentially being responsible for the ‘French paradox’—the observation that French people have a relatively low incidence of coronary heart disease, even though their diet is high in satur...