The emerging role of RNA modifications in the regulation of mRNA stability

• Published in: Experimental & molecular medicine Vol. 52; no. 3; pp. 400 - 408
• Main Authors: Boo, Sung Ho, Kim, Yoon Ki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2020; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 631/337/1645/2020; 631/337/1645/2570; Animals; Biomedical and Life Sciences; Biomedicine; Cytoplasm; Gene expression; Humans; Mammalian cells; Mammals - genetics; Medical Biochemistry; Molecular Medicine; Molecular modelling; mRNA stability; N6-methyladenosine; Nucleotide sequence; Review; Review Article; RNA - genetics; RNA modification; RNA Stability - genetics; RNA transport; RNA, Messenger - genetics; RNA-binding protein; RNA-Binding Proteins - genetics; Splicing; Stem Cells; Transcription; 생화학

Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs, and the accessibility of various RNA-binding pro...