Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

• Published in: BMC immunology Vol. 21; no. 1; pp. 55 - 16
• Main Authors: Kousha, Ahmad, Mahdavi Gorabi, Armita, Forouzesh, Mehdi, Hosseini, Mojgan, Alexander, Markov, Imani, Danyal, Razi, Bahman, Mousavi, Mohammad Javad, Aslani, Saeed, Mikaeili, Haleh
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.10.2020; BioMed Central; BMC
• Subjects: Asthma; B cells; Confidence intervals; Cytokines; Disease susceptibility; Ethnicity; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic susceptibility; Genotype & phenotype; Immunology; Interleukin 4; Interleukins; Literature reviews; Medical Subject Headings-MeSH; Meta-analysis; Minority & ethnic groups; Pathogenesis; Pediatrics; Polymorphism; Population; Risk factors; Statistical analysis; Interleukin 4; Genetic susceptibility; Asthma; Meta-analysis; Polymorphism

Numerous investigations have previously evaluated the association of interleukin (IL) 4 gene polymorphisms and the risk of asthma, conferring inconsistent results. To resolve the incongruent outcomes yielded from different single studies, we conducted the most up-to-date meta-analysis of IL4 gene -5...