Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture

• Published in: BMC microbiology Vol. 20; no. 1; pp. 120 - 19
• Main Authors: Caselli, Elisabetta, Fabbri, Chiara, D’Accolti, Maria, Soffritti, Irene, Bassi, Cristian, Mazzacane, Sante, Franchi, Maurizio
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.05.2020; BioMed Central; BMC
• Subjects: Analysis; Antibiotics; Bacteria; Buccal mucosa; Complexity; Disease; DNA microarrays; DNA sequencing; Drug resistance; Eukaryotes; Fungi; Gene sequencing; Genomes; Genomics; Lincosamides; Microbial drug resistance; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microhabitats; Microorganisms; Next-generation sequencing; Niches; Oral cavity; Oral drugs; Oral microbiome; Palate; Periodontics; Population; Precision medicine; Protozoa; Relative abundance; Resistome; RNA; rRNA 16S; Saliva; Site-specific microbiome map; Studies; Teeth; Tetracyclines; Toothbrushes; Viruses; Whole genome sequencing; Whole-genome sequencing (WGS); Young adults; Site-specific microbiome map; Resistome; Whole-genome sequencing (WGS); Oral microbiome

The microbiome of the oral cavity is the second-largest and diverse microbiota after the gut, harboring over 700 species of bacteria and including also fungi, viruses, and protozoa. With its diverse niches, the oral cavity is a very complex environment, where different microbes preferentially coloni...