Selective treatment pressure in colon cancer drives the molecular profile of resistant circulating tumor cell clones

• Published in: Molecular cancer Vol. 20; no. 1; pp. 30 - 6
• Main Authors: Cayrefourcq, Laure, Thomas, Frédéric, Mazard, Thibault, Assenat, Eric, Assou, Said, Alix-Panabières, Catherine
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.02.2021; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; 5-Fluorouracil; AKT protein; ALDOB; Biochemistry, Molecular Biology; Biomarkers; Biomarkers, Tumor; Biopsy; Cancer; Cancer therapies; CDA; Chemotherapy; Circulating tumor cells; Clonal evolution; Cloning; Colon cancer; Colonic Neoplasms; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colonic Neoplasms - therapy; Colorectal cancer; Computational Biology; Computational Biology - methods; Cytidine deaminase; Detoxification; Development and progression; Drug resistance; Drug Resistance, Neoplasm; Drug Resistance, Neoplasm - drug effects; Drug therapy; Energy metabolism; Enzymes; Gene expression; Gene Expression Profiling; Genes; Genomics; Human health and pathology; Humans; Hépatology and Gastroenterology; Letter to the Editor; Life Sciences; Liver; Liver Neoplasms; Liver Neoplasms - metabolism; Liver Neoplasms - secondary; Metabolism; Metastases; Metastasis; Neoplasm Metastasis; Neoplasm Staging; Neoplastic Cells, Circulating; Neoplastic Cells, Circulating - drug effects; Neoplastic Cells, Circulating - metabolism; Neoplastic Cells, Circulating - pathology; Patients; Peripheral blood; Physiological aspects; Precision medicine; Stem cells; TOR protein; Transcriptome; Tumor cells; Tumors; Xenobiotics; Clonal evolution; CDA; Colon cancer; ALDOB; Circulating tumor cells; Gene expression

The characterization of circulating tumor cells (CTCs) holds promises for precision medicine because these cells are an important clinical indicator of treatment efficacy. We established the first and still only nine permanent colon CTC lines from peripheral blood samples of a patient with metastati...