Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation

• Published in: Biomaterials Vol. 32; no. 1; pp. 48 - 56
• Main Authors: Bratt-Leal, Andrés M, Carpenedo, Richard L, Ungrin, Mark D, Zandstra, Peter W, McDevitt, Todd C
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2011
• Subjects: adhesion; Advanced Basic Science; agarose; Aggregates; Animals; biocompatible materials; Biocompatible Materials - pharmacology; cell aggregates; Cell Aggregation - drug effects; cell differentiation; Cell Differentiation - drug effects; Cell Survival - drug effects; cell suspension culture; cell viability; Cell-Derived Microparticles - metabolism; Cell-Derived Microparticles - ultrastructure; Cells, Cultured; cellular microenvironment; Dentistry; Differentiation; encapsulation; extracellular matrix; gelatin; gene expression; Gene Expression Regulation - drug effects; genes; hydrocolloids; medicine; Mice; Microparticles; Phenotype; Pluripotent stem cells; Pluripotent Stem Cells - cytology; Pluripotent Stem Cells - drug effects; Pluripotent Stem Cells - metabolism; protein synthesis; Spheroids; Spheroids, Cellular - metabolism; stem cells; tissue engineering; tissue repair; Aggregates; Pluripotent stem cells; Differentiation; Microparticles; Spheroids

Biomaterials are increasingly being used to engineer the biochemical and biophysical properties of the extracellular stem cell microenvironment in order to tailor niche characteristics and direct cell phenotype. To date, stem cell–biomaterial interactions have largely been studied by introducing ste...