Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 209 - 19
• Main Authors: Wu, Di, Chang, Xiao, Tian, Jingjing, Kang, Lin, Wu, Yuanhao, Liu, Jieying, Wu, Xiangdong, Huang, Yue, Gao, Bo, Wang, Hai, Qiu, Guixing, Wu, Zhihong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.07.2021; BioMed Central; BMC
• Subjects: Analysis; Angiogenesis; Angiogenesis Inducing Agents - pharmacology; Animals; Biomedical materials; Bone and Bones - drug effects; Bone growth; Bone healing; Bone regeneration; Bone Regeneration - drug effects; Bones; Cell Differentiation; Cell migration; Cell Movement; Cell Proliferation; Chemical properties; Collagen Type IV - metabolism; Computational Biology; Dental implants; Differentiation (biology); Dosage; Exosomes; Ferric oxide; Growth; Health aspects; Histone Deacetylases - metabolism; Humans; Iron; Iron oxides; Magnetic Fields; Magnetic nanoparticles; Magnetic properties; Magnetite Nanoparticles - chemistry; Male; Mesenchymal stem cells; Mesenchymal Stem Cells - drug effects; MicroRNA; MicroRNAs - metabolism; Microscopy; miR-1260a; miRNA; Morphology; Nanoparticles; Neovascularization; Osteogenesis; Osteogenesis - drug effects; Paracrine signalling; Rats; Regeneration; Regeneration (physiology); Static magnetic field; Stem cell transplantation; Stem cells; Stimulation; Testing; Tissue engineering; Transplantation; Ultracentrifugation; Wound Healing; China; United States > US; Japan; Germany; Static magnetic field; Exosomes; Bone regeneration; miR-1260a; Magnetic nanoparticles

The therapeutic potential of exosomes derived from stem cells has attracted increasing interest recently, because they can exert similar paracrine functions of stem cells and overcome the limitations of stem cells transplantation. Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) have be...