The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria

• Published in: PloS one Vol. 4; no. 9; p. e7167
• Main Authors: An, Dingding, Apidianakis, Yiorgos, Boechat, Ana Laura, Baldini, Regina L, Goumnerov, Boyan C, Rahme, Laurence G
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.09.2009; Public Library of Science (PLoS)
• Subjects: Amoeba; Animal models; Animals; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Arabidopsis; Arabidopsis - microbiology; Bacteria; Bacterial infections; Bacterial Proteins - metabolism; Bioinformatics; Burkholderia; Cholera; Cholera toxin; Computational Biology - methods; Conserved Sequence; Deoxyribonucleic acid; Detoxification; DNA; DNA biosynthesis; DNA repair; DNA replication; Drosophila melanogaster; Drosophila melanogaster - metabolism; Drug development; Enzymes; Epigenetics; Gene expression; Gene Expression Regulation, Bacterial; Genomes; Health aspects; Humans; Infection; Infections; Infectious Diseases/Bacterial Infections; Insects; Medical schools; Methyltransferase; Methyltransferases - genetics; Methyltransferases - physiology; Mice; Microbiology; Microbiology/Cellular Microbiology and Pathogenesis; Mutants; Pathogenesis; Pathogens; Phylogeny; Plants (botany); Proteins; Proteobacteria - metabolism; Pseudomonas aeruginosa; Pseudotuberculosis; Salmonella; Surgery; Transferases; Vibrio cholerae - metabolism; Virulence; Virulence (Microbiology); Virulence factors; Virulence Factors - metabolism; Waterborne diseases; Yersinia; Yersinia enterocolitica; Yersinia pseudotuberculosis; Yersinia pseudotuberculosis - metabolism; United States > US; Massachusetts

Identification of novel virulence factors is essential for understanding bacterial pathogenesis and designing antibacterial strategies. In this study, we uncover such a factor, termed KerV, in Proteobacteria. Experiments carried out in a variety of eukaryotic host infection models revealed that the...