Timing Constraints of In Vivo Gag Mutations during Primary HIV-1 Subtype C Infection

• Published in: PloS one Vol. 4; no. 11; p. e7727
• Main Authors: Novitsky, Vladimir, Wang, Rui, Margolin, Lauren, Baca, Jeannie, Kebaabetswe, Lemme, Rossenkhan, Raabya, Bonney, Caitlin, Herzig, Michaela, Nkwe, David, Moyo, Sikhulile, Musonda, Rosemary, Woldegabriel, Elias, van Widenfelt, Erik, Makhema, Joseph, Lagakos, Stephen, Essex, M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.11.2009; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Acute Disease; Adult; AIDS; Analysis; Cohort Studies; Completeness; Cytotoxicity; Dominance; Education; Female; gag Gene Products, Human Immunodeficiency Virus - genetics; Gene sequencing; Genetic aspects; Genome, Viral; Genomes; Genomics; Hazards; Health aspects; HIV; HIV Infections - genetics; HIV Infections - virology; HIV Seropositivity; HIV-1 - genetics; Human immunodeficiency virus; Humans; Immunology; In vivo methods and tests; Infection; Infections; Infectious diseases; Infectious Diseases/HIV Infection and AIDS; Infectious Diseases/Viral Infections; Lymphocytes; Male; Medical prognosis; Middle Aged; Molecular Biology/Molecular Evolution; Mutation; Public health; Sequence Analysis, DNA; Seroconversion; Statistical models; Studies; Time Factors; Trends; Virology/Immune Evasion; Virology/Immunodeficiency Viruses; Virology/Virus Evolution and Symbiosis; Viruses; United States > US; Massachusetts

Aiming to answer the broad question "When does mutation occur?" this study examined the time of appearance, dominance, and completeness of in vivo Gag mutations in primary HIV-1 subtype C infection. A primary HIV-1C infection cohort comprised of 8 acutely and 34 recently infected subjects...