Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot

• Published in: NeuroImage (Orlando, Fla.) Vol. 130; pp. 1 - 12
• Main Authors: Veronese, Mattia, Zanotti-Fregonara, Paolo, Rizzo, Gaia, Bertoldo, Alessandra, Innis, Robert B., Turkheimer, Federico E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2016; Elsevier Limited
• Subjects: Allen brain atlas; Brain mapping; Brain Mapping - methods; Brain research; Computer Simulation; Enzymes; Gene expression; Gene mapping; Humans; Lassen plot; Mathematical models; Models, Theoretical; mRNA; Neuroimaging; Non-displaceable binding; PET; Pharmacological blockade; Pharmacological displacement; Positron emission tomography; Positron-Emission Tomography - methods; Post-transcription; Proteins; Radioisotopes; Radiopharmaceuticals - analysis; Receptor density; Simulation; Studies; Tomography; Variables; Allen brain atlas; Pharmacological blockade; mRNA; Lassen plot; Pharmacological displacement; Non-displaceable binding; PET

PET studies allow in vivo imaging of the density of brain receptor species. The PET signal, however, is the sum of the fraction of radioligand that is specifically bound to the target receptor and the non-displaceable fraction (i.e. the non-specifically bound radioligand plus the free ligand in tiss...