Anti-cancer and anti-inflammatory effects elicited by short chain fatty acids produced by Escherichia coli isolated from healthy human gut microbiota

• Published in: Microbial cell factories Vol. 20; no. 1; pp. 36 - 17
• Main Authors: Nakkarach, Atchareeya, Foo, Hooi Ling, Song, Adelene Ai-Lian, Mutalib, Nur Elina Abdul, Nitisinprasert, Sunee, Withayagiat, Ulaiwan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.02.2021; BioMed Central; BMC
• Subjects: Acetic acid; Animal models; Anti-cancer; Anti-inflammatory; Anti-inflammatory agents; Anti-inflammatory drugs; Anticancer properties; Antimitotic agents; Antineoplastic agents; Bacteria; Biocompatibility; Biosynthesis; Breast cancer; Chromatography; Colon; Colon cancer; Colorectal cancer; Cytokines; Cytotoxicity; Digestive system; Disease; E coli; Escherichia coli; Exotoxins; Fatty acids; Gastrointestinal tract; Gene expression; Gut microbiota; Health aspects; Homeostasis; IL-1β; Inflammation; Interleukin 10; Interleukin 6; Interleukin 8; Intestinal microflora; Intestine; Leukemia; Lipopolysaccharides; Macrophages; Metabolism; Metabolites; Microbiological research; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Physiological aspects; Probiotics; Short chain fatty acid; Synthesis; Toxicity; Toxins; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Malaysia; Anti-cancer; Cytokines; Short chain fatty acid; Anti-inflammatory; Escherichia coli

Extracellular metabolites of short chain fatty acids (SCFA) excreted by gut microbiota have been reported to play an important role in the regulation of intestinal homeostasis. Apart from supplying energy, SCFA also elicit immune stimulation in animal and human cells. Therefore, an attempt was condu...