The thirsty fly: Ion transport peptide (ITP) is a novel endocrine regulator of water homeostasis in Drosophila

• Published in: PLoS genetics Vol. 14; no. 8; p. e1007618
• Main Authors: Gáliková, Martina, Dircksen, Heinrich, Nässel, Dick R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2018; Public Library of Science (PLoS)
• Subjects: Angiotensin; Animals; Antidiuretics; Biology and Life Sciences; Body fluids; Cellular signal transduction; Crustaceans; Dehydration; Desiccation; Drosophila; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila Proteins - genetics; Drosophila Proteins - physiology; Excretion; Female; Food intake; Gastrointestinal Tract - physiology; Gene Expression Regulation; Genetic aspects; Homeostasis; Hormones; Hunger; Insects; Investigations; Ion transport; Male; Medicine and Health Sciences; Neurons; Neuropeptides - genetics; Neuropeptides - physiology; Osmotic shock; Peptide hormones; Peptides; Renin; Research and Analysis Methods; RNA interference; Signal Transduction; Stress, Physiological; Thirst; Thirst - physiology; Vasopressin; Water; Water intake; Water resources; zoofysiologi; Zoological physiology; Sweden

Animals need to continuously adjust their water metabolism to the internal and external conditions. Homeostasis of body fluids thus requires tight regulation of water intake and excretion, and a balance between ingestion of water and solid food. Here, we investigated how these processes are coordina...