Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber - Nolte, Hendrik; Maloney, Jennifer; Nelson, Harold S.; Bernstein, David I.; Lu, Susan; Li, Ziliang; Kaur, Amarjot; Zieglmayer, Petra; Zieglmayer, René; Lemell, Patrick; Horak, Friedrich (Journal of allergy and clinical immunology, 2015)
Keywords: Adolescent; Adult; Allergen immunotherapy; Allergens - administration & dosage; Allergens - immunology; allergic rhinoconjunctivitis; Allergies; Allergy and Immunology; Animals; Antigens, Dermatophagoides - administration & dosage; Antigens, Dermatophagoides - immunology; Asthma - complications; Asthma - immunology; Asthma - physiopathology; Asthma - therapy; Atmosphere Exposure Chambers; Compliance; Conjunctivitis - complications; Conjunctivitis - immunology; Conjunctivitis - physiopathology; Conjunctivitis - therapy; Dermatophagoides pteronyssinus; Dermatophagoides pteronyssinus - chemistry; Dermatophagoides pteronyssinus - immunology; dose related; dose response; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug dosages; environmental exposure chamber; Female; house dust mite; Humans; Immunotherapy; Male; Middle Aged; nasal symptoms; ocular symptoms; onset of action; Pyroglyphidae - immunology; Rhinitis, Allergic - complications; Rhinitis, Allergic - immunology; Rhinitis, Allergic - physiopathology; Rhinitis, Allergic - therapy; Studies; Sublingual Immunotherapy; sublingual immunotherapy tablet; Tablets; Time Factors; Treatment Outcome; allergic rhinoconjunctivitis; VAS; environmental exposure chamber; HDM; ocular symptoms; DU; dose response; nasal symptoms; dose related; SCIT; EEC; SLIT; house dust mite; AE; onset of action; MID; RQLQ(S)12; AR; sublingual immunotherapy tablet; AAR; TSS; VCC; AR/C; Allergen immunotherapy; TOSS; TNSS; Vienna Challenge Chamber; Developmental units; Total symptom score; Visual analog scale; Total ocular symptom score; Active anterior rhinomanometry; Allergic rhinitis; Rhinoconjunctivitis Quality of Life Questionnaire with Standardized Activities for subjects ≥12 years old; Allergic rhinitis with or without conjunctivitis; Adverse event; Subcutaneous immunotherapy; Sublingual immunotherapy; Total nasal symptom score; Minimally important difference