Somatic evolutionary timings of driver mutations

• Published in: BMC cancer Vol. 18; no. 1; pp. 85 - 10
• Main Authors: Gomez, Karen, Miura, Sayaka, Huuki, Louise A, Spell, Brianna S, Townsend, Jeffrey P, Kumar, Sudhir
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.01.2018; BioMed Central; BMC
• Subjects: Analysis; Base Sequence - genetics; Carcinogenesis - genetics; Clonal Evolution - genetics; Development and progression; DNA sequencing; Driver mutation; Genetic aspects; Genetic Heterogeneity; Growth; Humans; Mutation; Mutation - genetics; Neoplasms - genetics; Neoplasms - pathology; Private mutation; Sequence Analysis, DNA; Somatic mutation; Tumors; Ubiquitous mutation; Driver mutation; Somatic mutation; Private mutation; Ubiquitous mutation

A unified analysis of DNA sequences from hundreds of tumors concluded that the driver mutations primarily occur in the earliest stages of cancer formation, with relatively few driver mutation events detected in the late-arising subclones. However, emerging evidence from the sequencing of multiple tu...