Cow’s milk neutralizes the cytotoxicity of acrolein, a putative carcinogen in cigarette smoke

• Published in: Journal of Veterinary Medical Science Vol. 80; no. 8; pp. 1301 - 1304
• Main Authors: MIZUTA, Ryushin, KIKU, Yoshio, HAYASHI, Tomohito
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2018; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Acrolein; Acrolein - antagonists & inhibitors; Adducts; Animals; Burkitt's lymphoma; Carcinogens; Carcinogens - antagonists & inhibitors; Cattle; Cell culture; Cigarette smoke; Cow's milk; Cytotoxicity; Esophagus; Female; Male; Milk; Milk - chemistry; Milk Proteins - chemistry; Necrosis; Protein adducts; Risk factors; Smoking - adverse effects; Tobacco smoke; Toxicology; cow’s milk; cytotoxicity; acrolein

Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow’s milk has been proposed as a protective factor. The mechanistic role of milk in preventing cancer, however, has not been clarified. We focused our study on acrolein, an abundant unsaturated a...