Cow’s milk neutralizes the cytotoxicity of acrolein, a putative carcinogen in cigarette smoke
Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow’s milk has been proposed as a protective factor. The mechanistic role of milk in preventing cancer, however, has not been clarified. We focused our study on acrolein, an abundant unsaturated a...
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| Published in | Journal of Veterinary Medical Science Vol. 80; no. 8; pp. 1301 - 1304 |
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| Format | Journal Article |
| Language | English |
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JAPANESE SOCIETY OF VETERINARY SCIENCE
2018
Japan Science and Technology Agency The Japanese Society of Veterinary Science |
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| Abstract | Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow’s milk has been proposed as a protective factor. The mechanistic role of milk in preventing cancer, however, has not been clarified. We focused our study on acrolein, an abundant unsaturated aldehyde present in cigarette smoke. Acrolein is a highly toxic compound and a putative carcinogen. Using a cell culture system, we found that (1) acrolein caused necrosis in Ramos Burkitt’s lymphoma cells, (2) the necrosis was inhibited by preincubation of acrolein with milk, and (3) acrolein formed adducts with milk proteins. These results indicated the protective effects of cow’s milk against acrolein-induced cytotoxicity via protein-acrolein adduct formation. |
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| AbstractList | Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the
consumption of cow’s milk has been proposed as a protective factor. The mechanistic role
of milk in preventing cancer, however, has not been clarified. We focused our study on
acrolein, an abundant unsaturated aldehyde present in cigarette smoke. Acrolein is a
highly toxic compound and a putative carcinogen. Using a cell culture system, we found
that (1) acrolein caused necrosis in Ramos Burkitt’s lymphoma cells, (2) the necrosis was
inhibited by preincubation of acrolein with milk, and (3) acrolein formed adducts with
milk proteins. These results indicated the protective effects of cow’s milk against
acrolein-induced cytotoxicity via protein-acrolein adduct formation. Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow’s milk has been proposed as a protective factor. The mechanistic role of milk in preventing cancer, however, has not been clarified. We focused our study on acrolein, an abundant unsaturated aldehyde present in cigarette smoke. Acrolein is a highly toxic compound and a putative carcinogen. Using a cell culture system, we found that (1) acrolein caused necrosis in Ramos Burkitt’s lymphoma cells, (2) the necrosis was inhibited by preincubation of acrolein with milk, and (3) acrolein formed adducts with milk proteins. These results indicated the protective effects of cow’s milk against acrolein-induced cytotoxicity via protein-acrolein adduct formation. Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow's milk has been proposed as a protective factor. The mechanistic role of milk in preventing cancer, however, has not been clarified. We focused our study on acrolein, an abundant unsaturated aldehyde present in cigarette smoke. Acrolein is a highly toxic compound and a putative carcinogen. Using a cell culture system, we found that (1) acrolein caused necrosis in Ramos Burkitt's lymphoma cells, (2) the necrosis was inhibited by preincubation of acrolein with milk, and (3) acrolein formed adducts with milk proteins. These results indicated the protective effects of cow's milk against acrolein-induced cytotoxicity via protein-acrolein adduct formation.Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow's milk has been proposed as a protective factor. The mechanistic role of milk in preventing cancer, however, has not been clarified. We focused our study on acrolein, an abundant unsaturated aldehyde present in cigarette smoke. Acrolein is a highly toxic compound and a putative carcinogen. Using a cell culture system, we found that (1) acrolein caused necrosis in Ramos Burkitt's lymphoma cells, (2) the necrosis was inhibited by preincubation of acrolein with milk, and (3) acrolein formed adducts with milk proteins. These results indicated the protective effects of cow's milk against acrolein-induced cytotoxicity via protein-acrolein adduct formation. |
| Author | HAYASHI, Tomohito MIZUTA, Ryushin KIKU, Yoshio |
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| Cites_doi | 10.1093/jnci/dji402 10.1371/journal.pmed.1000050 10.1016/j.mrfmmm.2003.07.001 10.1016/S0140-6736(80)92703-8 10.1016/S0090-9556(25)06899-0 10.2220/biomedres.30.165 10.1371/journal.pone.0080223 10.1038/sj.bjc.6602890 10.1002/0471142735.ima03bs21 10.1097/01.MP.0000068237.38715.D9 10.1111/1541-4337.12011 10.1073/pnas.95.9.4882 |
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| References | 8. Mizuta, R., Araki, S., Furukawa, M., Furukawa, Y., Ebara, S., Shiokawa, D., Hayashi, K., Tanuma, S. and Kitamura, D. 2013. DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One 8: e80223. 12. Strober, W. 2001. Trypan blue exclusion test of cell viability. Curr. Protoc. Immunol. Appendix 3Appendix: 3B. 2. Bryant, B. M., Jarman, M., Ford, H. T. and Smith, I. E. 1980. Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma. Lancet 2: 657–659. 3. Chung, F. L., Pan, J., Choudhury, S., Roy, R., Hu, W. and Tang, M. S. 2003. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat. Res. 531: 25–36. 4. Davoodi, H., Esmaeili, S. and Mortazavian, A. M. 2013. Effects of milk and milk products consumption on cancer: a review. Compr. Rev. Food Sci. Food Saf. 12: 249–264. 10. Mommers, M., Schouten, L. J., Goldbohm, R. A. and van den Brandt, P. A. 2006. Dairy consumption and ovarian cancer risk in the Netherlands Cohort Study on Diet and Cancer. Br. J. Cancer 94: 165–170. 14. Tanguay, C., Harvey, I., Houde, M., Srigley, J. R. and Têtu, B. 2003. Leiomyosarcoma of urinary bladder following cyclophosphamide therapy: report of two cases. Mod. Pathol. 16: 512–514. 15. Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E. and Osawa, T. 1998. Protein-bound acrolein: potential markers for oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 95: 4882–4887. 9. Mizuta, R., Mizuta, M., Araki, S., Suzuki, K., Ebara, S., Furukawa, Y., Shiokawa, D., Tanuma, S. and Kitamura, D. 2009. DNase gamma-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt’s lymphoma cell line. Biomed. Res. 30: 165–170. 7. Mitchell, D. Y. and Petersen, D. R. 1988. Inhibition of rat liver aldehyde dehydrogenases by acrolein. Drug Metab. Dispos. 16: 37–42. 1. Brooks, P. J., Enoch, M. A., Goldman, D., Li, T. K. and Yokoyama, A. 2009. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 6: e50. 13. Tang, M. S., Wang, H. T., Hu, Y., Chen, W. S., Akao, M., Feng, Z. and Hu, W. 2011. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol. Nutr. Food Res. 55: 1291–1300. 6. Gao, X., LaValley, M. P. and Tucker, K. L. 2005. Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J. Natl. Cancer Inst. 97: 1768–1777. 5. Fan, Y., Yuan, J. M., Wang, R., Gao, Y. T. and Yu, M. C. 2008. Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutr. Cancer 60: 354–363. 11. Qin, L. Q., Xu, J. Y., Wang, P. Y., Tong, J. and Hoshi, K. 2007. Milk consumption is a risk factor for prostate cancer in Western countries: evidence from cohort studies. Asia Pac. J. Clin. Nutr. 16: 467–476. 11 12 13 14 15 1 2 3 4 5 6 7 8 9 10 |
| References_xml | – reference: 10. Mommers, M., Schouten, L. J., Goldbohm, R. A. and van den Brandt, P. A. 2006. Dairy consumption and ovarian cancer risk in the Netherlands Cohort Study on Diet and Cancer. Br. J. Cancer 94: 165–170. – reference: 12. Strober, W. 2001. Trypan blue exclusion test of cell viability. Curr. Protoc. Immunol. Appendix 3Appendix: 3B. – reference: 5. Fan, Y., Yuan, J. M., Wang, R., Gao, Y. T. and Yu, M. C. 2008. Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutr. Cancer 60: 354–363. – reference: 13. Tang, M. S., Wang, H. T., Hu, Y., Chen, W. S., Akao, M., Feng, Z. and Hu, W. 2011. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol. Nutr. Food Res. 55: 1291–1300. – reference: 2. Bryant, B. M., Jarman, M., Ford, H. T. and Smith, I. E. 1980. Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma. Lancet 2: 657–659. – reference: 9. Mizuta, R., Mizuta, M., Araki, S., Suzuki, K., Ebara, S., Furukawa, Y., Shiokawa, D., Tanuma, S. and Kitamura, D. 2009. DNase gamma-dependent and -independent apoptotic DNA fragmentations in Ramos Burkitt’s lymphoma cell line. Biomed. Res. 30: 165–170. – reference: 15. Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E. and Osawa, T. 1998. Protein-bound acrolein: potential markers for oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 95: 4882–4887. – reference: 14. Tanguay, C., Harvey, I., Houde, M., Srigley, J. R. and Têtu, B. 2003. Leiomyosarcoma of urinary bladder following cyclophosphamide therapy: report of two cases. Mod. Pathol. 16: 512–514. – reference: 11. Qin, L. Q., Xu, J. Y., Wang, P. Y., Tong, J. and Hoshi, K. 2007. Milk consumption is a risk factor for prostate cancer in Western countries: evidence from cohort studies. Asia Pac. J. Clin. Nutr. 16: 467–476. – reference: 1. Brooks, P. J., Enoch, M. A., Goldman, D., Li, T. K. and Yokoyama, A. 2009. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 6: e50. – reference: 8. Mizuta, R., Araki, S., Furukawa, M., Furukawa, Y., Ebara, S., Shiokawa, D., Hayashi, K., Tanuma, S. and Kitamura, D. 2013. DNase γ is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One 8: e80223. – reference: 3. Chung, F. L., Pan, J., Choudhury, S., Roy, R., Hu, W. and Tang, M. S. 2003. Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutat. Res. 531: 25–36. – reference: 7. Mitchell, D. Y. and Petersen, D. R. 1988. Inhibition of rat liver aldehyde dehydrogenases by acrolein. Drug Metab. Dispos. 16: 37–42. – reference: 6. Gao, X., LaValley, M. P. and Tucker, K. L. 2005. Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis. J. Natl. Cancer Inst. 97: 1768–1777. – reference: 4. Davoodi, H., Esmaeili, S. and Mortazavian, A. M. 2013. Effects of milk and milk products consumption on cancer: a review. Compr. Rev. Food Sci. Food Saf. 12: 249–264. – ident: 5 – ident: 6 doi: 10.1093/jnci/dji402 – ident: 1 doi: 10.1371/journal.pmed.1000050 – ident: 11 – ident: 3 doi: 10.1016/j.mrfmmm.2003.07.001 – ident: 13 – ident: 2 doi: 10.1016/S0140-6736(80)92703-8 – ident: 7 doi: 10.1016/S0090-9556(25)06899-0 – ident: 9 doi: 10.2220/biomedres.30.165 – ident: 8 doi: 10.1371/journal.pone.0080223 – ident: 10 doi: 10.1038/sj.bjc.6602890 – ident: 12 doi: 10.1002/0471142735.ima03bs21 – ident: 14 doi: 10.1097/01.MP.0000068237.38715.D9 – ident: 4 doi: 10.1111/1541-4337.12011 – ident: 15 doi: 10.1073/pnas.95.9.4882 |
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| Snippet | Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow’s milk has been proposed as a protective factor.... Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow's milk has been proposed as a protective factor.... Cigarette smoke is a strong and independent risk factor for esophageal cancer, while the consumption of cow’s milk has been proposed as a protective factor.... |
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| SubjectTerms | Acrolein Acrolein - antagonists & inhibitors Adducts Animals Burkitt's lymphoma Carcinogens Carcinogens - antagonists & inhibitors Cattle Cell culture Cigarette smoke Cow's milk Cytotoxicity Esophagus Female Male Milk Milk - chemistry Milk Proteins - chemistry Necrosis Protein adducts Risk factors Smoking - adverse effects Tobacco smoke Toxicology |
| Title | Cow’s milk neutralizes the cytotoxicity of acrolein, a putative carcinogen in cigarette smoke |
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