Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

• Published in: Stem cell research & therapy Vol. 10; no. 1; p. 218
• Main Authors: Hladik, Daniela, Höfig, Ines, Oestreicher, Ursula, Beckers, Johannes, Matjanovski, Martina, Bao, Xuanwen, Scherthan, Harry, Atkinson, Michael J, Rosemann, Michael
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.07.2019; BioMed Central; BMC
• Subjects: Adult stem cells; Analysis; Cell differentiation; Clinical trials; DNA; DNA damage; DNA repair; Genetic instability; Genetic research; Ionizing radiation; Mesenchymal stem cells; Micronuclei; Regression analysis; Stem cell transplantation; Stem cells; Surgery; Germany; Ionizing radiation; Adult stem cells; Micronuclei; In vitro aging; Genetic instability; DNA repair; Mesenchymal stem cells

Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in vitro expansion of donor cells is usually necessary to furnish sufficient material for tra...