Toxic tau: structural origins of tau aggregation in Alzheimer's disease

• Published in: Neural regeneration research Vol. 15; no. 8; pp. 1417 - 1420
• Main Authors: Mamun, Abdullah, Uddin, Md, Mathew, Bijo, Ashraf, Ghulam
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.08.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Pharmakon Neuroscience Research Network, Dhaka, Bangladesh%Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, India%King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmacy, Southeast University, Dhaka, Bangladesh%Department of Pharmacy, Southeast University, Dhaka, Bangladesh; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Aggregates; Alzheimer's disease; alzheimer’s disease; neurofibrillary tangles; shape-shifting nature of tau; tau aggregation; toxic tau; Clinical trials; Diflunisal; Diseases; Gene expression; Heparan sulfate; Neurons; Pathogenesis; Pathology; Phosphorylation; Proteins; Researchers; Review; Seeds; Studies; Tafamidis; Tetracyclines; Alzheimer’s disease; shape-shifting nature of tau; tau aggregation; neurofibrillary tangles; toxic tau; Alzheimer's disease

Alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. Most of the Alzheimer's drugs targeting amyloid β have b...