Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects - Hamrouni, Sarra; Bras-Gonçalves, Rachel; Kidar, Abdelhamid; Aoun, Karim; Chamakh-Ayari, Rym; Petitdidier, Elodie; Messaoudi, Yasmine; Pagniez, Julie; Lemesre, Jean-Loup; Meddeb-Garnaoui, Amel (PLoS neglected tropical diseases, 2020)
Keywords: Adult; Antigenic determinants; Antigens; Antigens, Protozoan; Antigens, Protozoan - genetics; Antigens, Protozoan - immunology; Biology and Life Sciences; CD4 antigen; CD4-Positive T-Lymphocytes; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes - immunology; Cells; Cutaneous leishmaniasis; Cytokines; Deoxyribonucleic acid; Disease control; DNA; ELISA; Enzyme-Linked Immunosorbent Assay; Epitopes; Epitopes, T-Lymphocyte; Epitopes, T-Lymphocyte - genetics; Epitopes, T-Lymphocyte - immunology; Female; Flow Cytometry; Genetic testing; Granzyme B; Granzymes; Granzymes - analysis; Guanosine triphosphatases; Health aspects; Histocompatibility antigen HLA; Histocompatibility Antigens Class I; Histocompatibility Antigens Class I - metabolism; Histocompatibility Antigens Class II; Histocompatibility Antigens Class II - metabolism; Histones; HLA antigens; Humans; Identification; Immune response (cell-mediated); Immune system; Immunodominance; Immunogenicity; Immunological memory; Infections; Interferon-gamma; Interferon-gamma - analysis; Interleukin 10; Interleukin-10 - analysis; Leishmania; Leishmania - immunology; Leishmaniasis, Cutaneous; Leishmaniasis, Cutaneous - immunology; Leukocytes; Life Sciences; Lymphocytes; Lymphocytes T; Male; Medicine and Health Sciences; Memory cells; Middle Aged; Molecules; Parasites; Parasitic diseases; Peptides; Pharmacological research; Physiological aspects; Pools; Prevention; Protein Binding; Proteins; Public health; Recombinant Fusion Proteins; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Recombinant Fusion Proteins - metabolism; Research and Analysis Methods; Servers; T cells; Tropical diseases; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - analysis; Tumor necrosis factor-α; Vaccines; Vector-borne diseases; Volunteers; Young Adult; γ-Interferon; Tunisia; France; Germany