Dissolution of spiral wave’s core using cardiac optogenetics

• Published in: PLoS computational biology Vol. 19; no. 12; p. e1011660
• Main Authors: Hussaini, Sayedeh, Lädke, Sarah L., Schröder-Schetelig, Johannes, Venkatesan, Vishalini, Quiñonez Uribe, Raúl A., Richter, Claudia, Majumder, Rupamanjari, Luther, Stefan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2023; Public Library of Science (PLoS)
• Subjects: Action potential; Animal welfare; Arrhythmia; Biology and Life Sciences; Cardiac arrhythmia; Cardiomyocytes; Development and progression; Diagnosis; Experiments; Genetics; Health aspects; Heart; Information processing; Laboratory animals; Light; Luminous intensity; Medicine and Health Sciences; Numerical analysis; Optics; Partial differential equations; Physical Sciences; Prolongation; Research and Analysis Methods; Tachycardia; Ventricle; Germany

Rotating spiral waves in the heart are associated with life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation. These arrhythmias are treated by a process called defibrillation, which forces electrical resynchronization of the heart tissue by delivering a single global...