USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16

• Published in: PLoS pathogens Vol. 19; no. 7; p. e1011480
• Main Authors: Fu, Yuling, Zhan, Xiaoxia, You, Xiaolong, Nie, Dingnai, Mai, Haiyan, Chen, Yitian, He, Shitong, Sheng, Junli, Zeng, Zhijie, Li, Hongwei, Li, Jinlong, Hu, Shengfeng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2023; Public Library of Science (PLoS)
• Subjects: Antiviral drugs; Apoptosis; Bats; Biological response modifiers; Biology and life sciences; Cell growth; Chemokines; Cytokines; Deoxyribonucleic acid; Disease susceptibility; DNA; Genes; Health aspects; Herpes viruses; Immune response; Immune system; Infection; Infections; Interferon; Interferon regulatory factor 3; Interleukin 6; Medicine and Health Sciences; Nucleic acids; Plasmids; Proteases; Proteasomes; Proteins; Research and Analysis Methods; Sensors; Signal transduction; Ubiquitin; Ubiquitin-specific proteinase; Viral infections; Virus diseases; Viruses; β-Interferon; China

Deubiquitinating enzymes (DUBs) regulate antiviral immune response through targeting DNA sensor signaling pathway members. As one of the DNA sensors, interferon (IFN)-γ inducible protein 16 (IFI16) play a major role in response to virus infections through activating the canonical STING/TBK-1/IRF3 si...