Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota

• Published in: Molecules (Basel, Switzerland) Vol. 21; no. 11; p. 1419
• Main Authors: Tung, Yen-Chen, Lin, Yu-Hsuan, Chen, Hong-Jhang, Chou, Shen-Chieh, Cheng, An-Chin, Kalyanam, Nagabhushanam, Ho, Chi-Tang, Pan, Min-Hsiung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.10.2016; MDPI
• Subjects: Adenosine; Adipocytes; Adipogenesis - drug effects; AMPK; Animals; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - pharmacology; Body fat; Body Weight - drug effects; C57BL/6; Cholesterol - blood; Diet, High-Fat - adverse effects; Disease Models, Animal; Dose-Response Relationship, Drug; Eating - drug effects; Energy; Enzymes; Fatty acids; Firmicutes; Food; Gastrointestinal Microbiome - drug effects; Gene Expression Regulation - drug effects; Glucose; gut microbiota; high-fat diet; Homeostasis; Investigations; Kinases; Lactobacillus; Lipids; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Liver; Mice; Mice, Inbred C57BL; Microbiota; Nutrition research; Obesity; Obesity - chemically induced; Obesity - drug therapy; Obesity - metabolism; Organ Size - drug effects; Oxidation; Phosphorylation; piceatannol; Proteins; Stilbenes - administration & dosage; Stilbenes - pharmacology; Transcription factors; United States > US; China; Taiwan; AMPK; piceatannol; C57BL/6; gut microbiota; obesity; high-fat diet

Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse b...