Requirement of RIZ1 for cancer prevention by methyl-balanced diet

• Published in: PloS one Vol. 3; no. 10; p. e3390
• Main Authors: Zhou, Wenyun, Alonso, Sergio, Takai, Daisaku, Lu, Shelly C, Yamamoto, Fumiichiro, Perucho, Manuel, Huang, Shi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.10.2008; Public Library of Science (PLoS)
• Subjects: Adenosylmethionine; Adenoviruses; Amino acids; Animals; c-Jun protein; Cancer; Cancer prevention; Carcinogenesis; Carcinogens; Chromatin; Comparative analysis; Deoxyribonucleic acid; Diet; Disease prevention; DNA; DNA methylation; DNA microarrays; DNA-Binding Proteins - deficiency; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Enzymes; Food; Gastroenterology and Hepatology/Gastrointestinal Cancers; Gene expression; Gene Expression Regulation; Gene silencing; Genes; Genomes; Health aspects; Histone H3; Histone-Lysine N-Methyltransferase; Liver; Liver cancer; Liver diseases; Lymphoma; Lysine; Medical research; Metabolites; Methionine - administration & dosage; Methylation; Methyltransferases; Mice; Mice, Knockout; Neoplasms - prevention & control; Nuclear Proteins - deficiency; Nuclear Proteins - genetics; Nuclear Proteins - physiology; Nutrients; Nutrition/Malnutrition; Oncology; Prevention; Proteins; Rodentia; Rodents; S-Adenosylmethionine; Senescence; Transcription factors; Transcription Factors - deficiency; Transcription Factors - genetics; Transcription Factors - physiology; Tumor suppressor genes; Tumors; Vitamin B; La Jolla California; United States > US; California

The typical Western diet is not balanced in methyl nutrients that regulate the level of the methyl donor S-adenosylmethionine (SAM) and its derivative metabolite S-adenosylhomocysteine (SAH), which in turn may control the activity of certain methyltransferases. Feeding rodents with amino acid define...