Cytokine-induced memory-like natural killer cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 6; pp. 1915 - 1919
• Main Authors: Cooper, Megan A, Elliott, Julie M, Keyel, Peter A, Yang, Liping, Carrero, Javier A, Yokoyama, Wayne M
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 10.02.2009; National Acad Sciences
• Subjects: Adoptive transfer; Animals; Antigens; Biological Sciences; Cells; Cytokines; Cytokines - immunology; Granzymes - analysis; Immune system; Immunity, Innate; Immunologic Memory; Infections; Innate immunity; Interferon-gamma - biosynthesis; Killer Cells, Natural - immunology; Killer Cells, Natural - transplantation; Lymphocyte Activation - immunology; Lymphocyte Transfusion; Lymphocytes; Memory; Mice; Mice, Knockout; Natural killer cells; Pathogens; Receptors

The mammalian immune response to infection is mediated by 2 broad arms, the innate and adaptive immune systems. Innate immune cells are a first-line defense against pathogens and are thought to respond consistently to infection, regardless of previous exposure, i.e., they do not exhibit memory of pr...