Decreased Expression of Sprouty2 in the Dorsolateral Prefrontal Cortex in Schizophrenia and Bipolar Disorder: A Correlation with BDNF Expression

• Published in: PloS one Vol. 3; no. 3; p. e1784
• Main Author: Pillai, Anilkumar
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.03.2008; Public Library of Science (PLoS)
• Subjects: Abnormalities; Analysis; Animals; Antipsychotic Agents - therapeutic use; Antipsychotics; Base Sequence; Bipolar disorder; Bipolar Disorder - drug therapy; Bipolar Disorder - metabolism; Brain; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Cellular signal transduction; Correlation; Cortex (frontal); DNA Primers; Drugs; Functional plasticity; Gene expression; Genes; Haloperidol; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Kinases; Male; Membrane Proteins; Mental disorders; Mental Health/Mood Disorders; Mental Health/Neuropsychiatric Disorders; Mental Health/Psychopharmacology; Mental Health/Schizophrenia and Other Psychoses; Myelination; Neural plasticity; Neuroplasticity; Neuroscience/Cognitive Neuroscience; Neuroscience/Neurodevelopment; Olanzapine; Prefrontal cortex; Prefrontal Cortex - metabolism; Psychotropic drugs; Rats; Regulatory mechanisms (biology); Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA, Messenger - genetics; Rodents; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - metabolism; Signal transduction; Synaptic plasticity

Current theories on the pathophysiology of schizophrenia suggest altered brain plasticity such as decreased neural proliferation and migration, delayed myelination, and abnormal synaptic modeling, in the brain of subjects with schizophrenia. Though functional alterations in BDNF, which plays importa...