Seroepidemiology of non-primate hepacivirus (NPHV) in Japanese native horses

Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is s...

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Published inJournal of Veterinary Medical Science Vol. 80; no. 1; pp. 186 - 189
Main Authors HAYASHI, Shizuka, TANAKA, Tomohisa, MORIISHI, Kohji, HIRAYAMA, Kazuhiro, YAMADA, Akio, HOTTA, Kozue
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2018
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Antibodies
Core protein
Hepatitis
Hepatitis C
Homology
Horses
Japanese native horse
non-primate hepacivirus
Pedigree
Seroepidemiology
Virology
Viruses
seroepidemiology
non-primate hepacivirus
Japanese native horse
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Abstract Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is still unknown. In this study, seroepidemiological study of NPHV was conducted using 335 sera from five breeds of Japanese native horses. These horses are maintained as the pedigree and are reared apart from other horse breeds. The detection of antibodies against NPHV were conducted by western blot analysis using the recombinant protein of the NPHV core protein. The antibodies against NPHV were detected in all five breeds, 83 out of 335 (23.4%) horses. These results suggested that NPHV was circulating among Japanese native horses.
AbstractList Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is still unknown. In this study, seroepidemiological study of NPHV was conducted using 335 sera from five breeds of Japanese native horses. These horses are maintained as the pedigree and are reared apart from other horse breeds. The detection of antibodies against NPHV were conducted by western blot analysis using the recombinant protein of the NPHV core protein. The antibodies against NPHV were detected in all five breeds, 83 out of 335 (23.4%) horses. These results suggested that NPHV was circulating among Japanese native horses.
Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is still unknown. In this study, seroepidemiological study of NPHV was conducted using 335 sera from five breeds of Japanese native horses. These horses are maintained as the pedigree and are reared apart from other horse breeds. The detection of antibodies against NPHV were conducted by western blot analysis using the recombinant protein of the NPHV core protein. The antibodies against NPHV were detected in all five breeds, 83 out of 335 (23.4%) horses. These results suggested that NPHV was circulating among Japanese native horses.
Author HAYASHI, Shizuka
YAMADA, Akio
MORIISHI, Kohji
HIRAYAMA, Kazuhiro
TANAKA, Tomohisa
HOTTA, Kozue
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  organization: Department of Microbiology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
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  fullname: MORIISHI, Kohji
  organization: Department of Microbiology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan
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  fullname: HIRAYAMA, Kazuhiro
  organization: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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  fullname: YAMADA, Akio
  organization: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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  organization: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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Keywords seroepidemiology
non-primate hepacivirus
Japanese native horse
Language English
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SubjectTerms Antibodies
Core protein
Hepatitis
Hepatitis C
Homology
Horses
Japanese native horse
non-primate hepacivirus
Pedigree
Seroepidemiology
Virology
Viruses
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