Characterization of Myxovirus resistance protein in birds showing different susceptibilities to highly pathogenic influenza virus

• Published in: Journal of Veterinary Medical Science Vol. 82; no. 5; pp. 619 - 625
• Main Authors: ONUMA, Manabu, NAKAYA, Takaaki, HAGIWARA, Katsuro
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2020; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: 3T3 Cells; Amino Acid Sequence; Animals; Antiviral activity; Antiviral agents; Avian flu; Birds; Cell proliferation; Cells, Cultured; Copy number; Disease resistance; highly pathogenic avian influenza virus; Immune response; Infections; Infectivity; Influenza; Influenza A Virus, H5N1 Subtype - growth & development; Influenza A Virus, H5N1 Subtype - immunology; Influenza in Birds - immunology; Influenza in Birds - virology; loop L4; Mice; Mx gene; Mx protein; Myxovirus resistance proteins; Myxovirus Resistance Proteins - chemistry; Myxovirus Resistance Proteins - genetics; Myxovirus Resistance Proteins - metabolism; Protein Conformation; Protein structure; Proteins; RNA, Viral; Species; Species Specificity; Viral infections; Wildlife Science; highly pathogenic avian influenza virus; Mx gene; Mx protein; loop L4

We compared the Mx expression and anti-viral function and the 3D structure of Mx protein in four species: chicken (Gallus gallus), whooper swan (Cygnus cygnus), jungle crow (Corvus macrorhynchos), and rock dove (Columba livia). We observed different mortalities associated with highly pathogenic avia...