Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs - Giordani, Federica; Paape, Daniel; Vincent, Isabel M.; Pountain, Andrew W.; Fernández-Cortés, Fernando; Rico, Eva; Zhang, Ning; Morrison, Liam J.; Freund, Yvonne; Witty, Michael J.; Peter, Rosemary; Edwards, Darren Y.; et al. (PLoS pathogens, 2020)
Keywords: Aldehyde dehydrogenase; Aldehydes; Analysis; Animals; Biology and Life Sciences; Boron Compounds - metabolism; Carboxylic Acids - metabolism; Carboxypeptidase; Carboxypeptidases - metabolism; Chemical compounds; Chemical properties; Chromosome 10; Chromosomes; Cloning; Dosage and administration; Drug dosages; Drug Resistance; Drug therapy; Drugs; Enzyme activation; Female; Forecasts and trends; Gene sequencing; Genes; Genomes; Identification and classification; Infectious diseases; Influence; Livestock; Metabolism; Metabolomics; Methionine; Methylation; Mice; Nucleotide sequence; Parasitemia - veterinary; Parasites; Peptidase; Peptidases; Peptides; Physical Sciences; Prodrugs; Prodrugs - metabolism; Proteases; Protozoan Proteins - metabolism; Research and Analysis Methods; RNA processing; Serine; Serine carboxypeptidase; Splicing; Synteny; Trypanocidal Agents - metabolism; Trypanosoma; Trypanosoma brucei brucei - drug effects; Trypanosoma brucei brucei - enzymology; Trypanosoma congolense - drug effects; Trypanosoma congolense - enzymology; Trypanosoma vivax - drug effects; Trypanosoma vivax - enzymology; Trypanosomiasis, African - drug therapy; Trypanosomiasis, African - parasitology; Trypanosomiasis, African - veterinary; Valine - analogs & derivatives; Valine - metabolism; Veterinary research; Whole genome sequencing; United Kingdom