The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence

• Published in: PLoS pathogens Vol. 16; no. 7; p. e1008645
• Main Authors: Ries, Laure N. A., Pardeshi, Lakhansing, Dong, Zhiqiang, Tan, Kaeling, Steenwyk, Jacob L., Colabardini, Ana Cristina, Ferreira Filho, Jaire A., de Castro, Patricia A., Silva, Lilian P., Preite, Nycolas W., Almeida, Fausto, de Assis, Leandro J., dos Santos, Renato A. C., Bowyer, Paul, Bromley, Michael, Owens, Rebecca A., Doyle, Sean, Demasi, Marilene, Hernández, Diego C. R., Netto, Luís Eduardo S., Pupo, Monica T., Rokas, Antonis, Loures, Flavio V., Wong, Koon H., Goldman, Gustavo H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2020; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Aspergillosis; Aspergillosis - metabolism; Aspergillosis - microbiology; Aspergillus; Aspergillus fumigatus; Aspergillus fumigatus - metabolism; Aspergillus fumigatus - pathogenicity; Bioinformatics; Biology; Biology and Life Sciences; Biosynthesis; Chemotherapy; Clusters; Cytokines; Defects; Enzymes; Fungal infections; Fungal Proteins - metabolism; Fungi; Gene expression; Gene Expression Regulation, Fungal - physiology; Genes; Genetic aspects; Genomics; Gliotoxin; Gliotoxin - biosynthesis; Granulocytes; Health aspects; Health sciences; Homology; Immune response; Immune system; Immunomodulation; Kinases; Medicine; Medicine and Health Sciences; Metabolites; Mice; Model testing; Neutrophils; Opportunist infection; Oxidation resistance; Oxidative stress; Oxidative Stress - physiology; Oxidoreductase; Pathogens; Pharmaceutical sciences; Phylogeny; Secondary metabolites; Transcription factors; Transcription Factors - metabolism; Virulence; Virulence - physiology; Brazil; United Kingdom > UK; United States > US; Ireland; China; Macao; Nashville Tennessee

Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recr...