The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence - Ries, Laure N. A.; Pardeshi, Lakhansing; Dong, Zhiqiang; Tan, Kaeling; Steenwyk, Jacob L.; Colabardini, Ana Cristina; Ferreira Filho, Jaire A.; de Castro, Patricia A.; Silva, Lilian P.; Preite, Nycolas W.; Almeida, Fausto; de Assis, Leandro J.; et al. (PLoS pathogens, 2020)
Keywords: Animal models; Animals; Aspergillosis; Aspergillosis - metabolism; Aspergillosis - microbiology; Aspergillus; Aspergillus fumigatus; Aspergillus fumigatus - metabolism; Aspergillus fumigatus - pathogenicity; Bioinformatics; Biology; Biology and Life Sciences; Biosynthesis; Chemotherapy; Clusters; Cytokines; Defects; Enzymes; Fungal infections; Fungal Proteins - metabolism; Fungi; Gene expression; Gene Expression Regulation, Fungal - physiology; Genes; Genetic aspects; Genomics; Gliotoxin; Gliotoxin - biosynthesis; Granulocytes; Health aspects; Health sciences; Homology; Immune response; Immune system; Immunomodulation; Kinases; Medicine; Medicine and Health Sciences; Metabolites; Mice; Model testing; Neutrophils; Opportunist infection; Oxidation resistance; Oxidative stress; Oxidative Stress - physiology; Oxidoreductase; Pathogens; Pharmaceutical sciences; Phylogeny; Secondary metabolites; Transcription factors; Transcription Factors - metabolism; Virulence; Virulence - physiology; Brazil; United Kingdom--UK; United States--US; Ireland; China; Macao; Nashville Tennessee