Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

• Published in: Pharmaceutical biology Vol. 57; no. 1; pp. 193 - 225
• Main Authors: Wang, Jin, Wang, Lin, Lou, Guan-Hua, Zeng, Hai-Rong, Hu, Ju, Huang, Qin-Wan, Peng, Wei, Yang, Xiang-Bo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2019; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Alkaloids; Animals; Antidiabetics; Apoptosis; Berberine; Bone cancer; China; Chromatography; Coptis; Coptis - chemistry; Coptis chinensis; coumarins; Diabetes; Diabetes mellitus; Drugs, Chinese Herbal - adverse effects; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Dysentery; Eczema; Herbal medicine; herbal medicines; Huanglian; Humans; Ischemia; Mass spectrometry; Medicine, Chinese Traditional - methods; Metabolism; Metabolites; morphology; Organic acids; Oriental traditional medicine; Pertussis; Pharmacokinetics; Pharyngitis; Phenylpropanoids; Phytotherapy - methods; plant biochemistry; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Quality control; Quinones; Review; Rhizome; Rhizomes; Scientific imaging; toxicity; China; toxicity; pharmacokinetics; morphology; alkaloids; Huanglian; berberine

Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Obj...