Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Obj...

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Published inPharmaceutical biology Vol. 57; no. 1; pp. 193 - 225
Main Authors Wang, Jin, Wang, Lin, Lou, Guan-Hua, Zeng, Hai-Rong, Hu, Ju, Huang, Qin-Wan, Peng, Wei, Yang, Xiang-Bo
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2019
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Alkaloids
Animals
Antidiabetics
Apoptosis
Berberine
Bone cancer
China
Chromatography
Coptis
Coptis - chemistry
Coptis chinensis
coumarins
Diabetes
Diabetes mellitus
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
Dysentery
Eczema
Herbal medicine
herbal medicines
Huanglian
Humans
Ischemia
Mass spectrometry
Medicine, Chinese Traditional - methods
Metabolism
Metabolites
morphology
Organic acids
Oriental traditional medicine
Pertussis
Pharmacokinetics
Pharyngitis
Phenylpropanoids
Phytotherapy - methods
plant biochemistry
Plant Extracts - adverse effects
Plant Extracts - chemistry
Plant Extracts - pharmacology
Quality control
Quinones
Review
Rhizome
Rhizomes
Scientific imaging
toxicity
China
toxicity
pharmacokinetics
morphology
alkaloids
Huanglian
berberine
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Abstract Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
AbstractList Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China.Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives.Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread.Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR.Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis , Coptidis Rhizoma, Huanglian , and goldthread. Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China.CONTEXTCoptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China.The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives.OBJECTIVESThe present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives.Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread.METHODSStudies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread.Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR.RESULTSCurrently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR.As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.CONCLUSIONSAs an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. Objectives: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. Methods: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. Results: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. Conclusions: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.
Author Zeng, Hai-Rong
Yang, Xiang-Bo
Wang, Jin
Huang, Qin-Wan
Wang, Lin
Peng, Wei
Lou, Guan-Hua
Hu, Ju
Author_xml – sequence: 1
  givenname: Jin
  surname: Wang
  fullname: Wang, Jin
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 2
  givenname: Lin
  surname: Wang
  fullname: Wang, Lin
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 3
  givenname: Guan-Hua
  surname: Lou
  fullname: Lou, Guan-Hua
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 4
  givenname: Hai-Rong
  surname: Zeng
  fullname: Zeng, Hai-Rong
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 5
  givenname: Ju
  surname: Hu
  fullname: Hu, Ju
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 6
  givenname: Qin-Wan
  surname: Huang
  fullname: Huang, Qin-Wan
  email: hqwan2163@163.com, pengwei002@126.com
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 7
  givenname: Wei
  surname: Peng
  fullname: Peng, Wei
  email: hqwan2163@163.com, pengwei002@126.com
  organization: College of Pharmacy, Chengdu University of Traditional Chinese Medicine
– sequence: 8
  givenname: Xiang-Bo
  surname: Yang
  fullname: Yang, Xiang-Bo
  organization: Ya'an Xun Kang Pharmaceutical Co., Ltd
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30963783$$D View this record in MEDLINE/PubMed
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Keywords toxicity
pharmacokinetics
morphology
alkaloids
Huanglian
berberine
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Snippet Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta...
Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall...
Context: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta...
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SubjectTerms Alkaloids
Animals
Antidiabetics
Apoptosis
Berberine
Bone cancer
China
Chromatography
Coptis
Coptis - chemistry
Coptis chinensis
coumarins
Diabetes
Diabetes mellitus
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
Dysentery
Eczema
Herbal medicine
herbal medicines
Huanglian
Humans
Ischemia
Mass spectrometry
Medicine, Chinese Traditional - methods
Metabolism
Metabolites
morphology
Organic acids
Oriental traditional medicine
Pertussis
Pharmacokinetics
Pharyngitis
Phenylpropanoids
Phytotherapy - methods
plant biochemistry
Plant Extracts - adverse effects
Plant Extracts - chemistry
Plant Extracts - pharmacology
Quality control
Quinones
Review
Rhizome
Rhizomes
Scientific imaging
toxicity
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Title Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
URI https://www.tandfonline.com/doi/abs/10.1080/13880209.2019.1577466
https://www.ncbi.nlm.nih.gov/pubmed/30963783
https://www.proquest.com/docview/2391267458
https://www.proquest.com/docview/2206230199
https://www.proquest.com/docview/2439428636
https://pubmed.ncbi.nlm.nih.gov/PMC6461078
https://doaj.org/article/1fc89fce1cae4ea1b295992c0aca0bea
Volume 57
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