Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease

• Published in: Biochimica et biophysica acta Vol. 1820; no. 9; pp. 1366 - 1372
• Main Authors: Carlsson, Michael C., Balog, Crina I.A., Kilsgård, Ola, Hellmark, Thomas, Bakoush, Omran, Segelmark, Mårten, Fernö, Mårten, Olsson, Håkan, Malmström, Johan, Wuhrer, Manfred, Leffler, Hakon
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2012
• Subjects: affinity chromatography; Biologi; Biological Sciences; Biomarkers; Biomarkers - blood; Biomarkers - metabolism; Blood Proteins - metabolism; blood serum; breast neoplasms; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Cancer; Cancer and Oncology; Cancer och onkologi; Carcinoma - blood; Carcinoma - diagnosis; Carcinoma - pathology; Case-Control Studies; Chromatography, Affinity; Clinical Medicine; Female; Galectin 1 - metabolism; Galectin-1; Galectin-8; Galectins - metabolism; glomerulonephritis; Glycoproteins - blood; Glycoproteins - metabolism; glycosylation; haptoglobins; Humans; IgA-nephropathy; inflammation; Inflammation - diagnosis; Inflammation - metabolism; Inflammation - pathology; Klinisk medicin; Medical and Health Sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; metastasis; Natural Sciences; Naturvetenskap; Neoplasm Metastasis; Neoplasms - diagnosis; Neoplasms - metabolism; Neoplasms - pathology; patients; Protein Binding - physiology; Serum - chemistry; Serum - metabolism; Serum glycoprotein; women; Galectin-8; IgA-nephropathy; CRD; Galectin-8N; Biomarkers; IgAN; Galectin-1; Serum glycoprotein; Cancer

Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter...