Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

• Published in: Genome Biology Vol. 17; no. 1; p. 58
• Main Authors: Wang, Huiling, Chao, Kang, Ng, Siew Chien, Bai, Alfa Hc, Yu, Qiao, Yu, Jun, Li, Manying, Cui, Yi, Chen, Minhu, Hu, Ji-Fan, Zhang, Shenghong
• Format: Journal Article
• Language: English
• Published: England BioMed Central 30.03.2016
• Subjects: Animals; Antagomirs; antibodies; Caco-2 Cells; Cell adhesion & migration; Cell Line; Claudins - genetics; Claudins - metabolism; Colitis; Colon; Cytokines; Disease Models, Animal; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation; Helper cells; Humans; Hypoxia; immunohistochemistry; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - chemically induced; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - metabolism; Interleukin 23; Interleukin-23 - administration & dosage; Interleukin-23 - genetics; Interleukin-23 - pharmacology; Intestine; Lymphocytes T; Mice; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Mucosa; multigene family; Oligonucleotide Array Sequence Analysis - methods; Oligonucleotides - administration & dosage; Oligonucleotides - therapeutic use; Pathogenesis; patients; Permeability; Ribonucleic acid; RNA; Rodents; Signal Transduction; staining; sulfonic acids; Tight junctions; Trinitrobenzenesulfonic Acid - adverse effects; Tumor necrosis factor-TNF; Asia; Interleukin 23; miRNA; Pathway; Crohn’s disease; Ulcerative colitis

The IL23/Th17 pathway is essential for the onset of inflammatory bowel disease (IBD), yet the specific mechanism by which this pathway initiates the disease remains unknown. In this study, we identify the mechanisms that mediate cross-talk between the IL23 pathway and the intestinal barrier in IBD....