Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of...
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| Published in | Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 372; no. 1715; p. 20160153 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Royal Society
05.03.2017
The Royal Society Publishing |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.
This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’. |
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| AbstractList | Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’. Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’. |
| Author | Mizusaki, Beatriz E. P. Sjöström, P. Jesper Costa, Rui Ponte van Rossum, Mark C. W. |
| AuthorAffiliation | 3 Instituto de Física , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil 1 Institute for Adaptive and Neural Computation , School of Informatics University of Edinburgh , Edinburgh , UK 4 Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Program for Brain Repair and Integrative Neuroscience , The Research Institute of the McGill University Health Centre, McGill University , Montreal, Quebec , Canada 2 Centre for Neural Circuits and Behaviour , University of Oxford , Oxford , UK |
| AuthorAffiliation_xml | – name: 1 Institute for Adaptive and Neural Computation , School of Informatics University of Edinburgh , Edinburgh , UK – name: 2 Centre for Neural Circuits and Behaviour , University of Oxford , Oxford , UK – name: 4 Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Program for Brain Repair and Integrative Neuroscience , The Research Institute of the McGill University Health Centre, McGill University , Montreal, Quebec , Canada – name: 3 Instituto de Física , Universidade Federal do Rio Grande do Sul , Porto Alegre , Brazil |
| Author_xml | – sequence: 1 givenname: Rui Ponte orcidid: 0000-0003-2595-2027 surname: Costa fullname: Costa, Rui Ponte organization: Institute for Adaptive and Neural Computation, School of Informatics University of Edinburgh, Edinburgh, UK; Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK – sequence: 2 givenname: Beatriz E. P. surname: Mizusaki fullname: Mizusaki, Beatriz E. P. organization: Instituto de Física, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Program for Brain Repair and Integrative Neuroscience, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada – sequence: 3 givenname: P. Jesper orcidid: 0000-0001-7085-2223 surname: Sjöström fullname: Sjöström, P. Jesper organization: Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Program for Brain Repair and Integrative Neuroscience, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada – sequence: 4 givenname: Mark C. W. orcidid: 0000-0001-6525-6814 surname: van Rossum fullname: van Rossum, Mark C. W. email: mvanross@inf.ed.ac.uk organization: Institute for Adaptive and Neural Computation, School of Informatics University of Edinburgh, Edinburgh, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28093547$$D View this record in MEDLINE/PubMed |
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| Keywords | synaptic release synaptic plasticity Hebbian plasticity spike-timing-dependent plasticity homoeostatic plasticity long-term potentiation |
| Language | English |
| License | open-access: Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
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| Notes | Discussion meeting issue ‘Integrating Hebbian and homeostatic plasticity’ organized and edited by Kevin Fox and Michael Stryker ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 One contribution of 16 to a discussion meeting issue ‘Integrating Hebbian and homeostatic plasticity’. |
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| Snippet | Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this... |
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| SubjectTerms | Animals Functional plasticity Hebbian Plasticity Homeostasis Homeostatic plasticity Homoeostatic Plasticity Humans Loci Long-Term Potentiation Memory Models, Neurological Neuronal Plasticity Plasticity Reaction Time Review Sensation Sensory perception Spike-Timing-Dependent Plasticity Synaptic Plasticity Synaptic Release |
| Title | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
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