A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1

• Published in: Genome Biology Vol. 19; no. 1; p. 218
• Main Authors: Chen, Naifei, Zhao, Gang, Yan, Xu, Lv, Zheng, Yin, Hongmei, Zhang, Shilin, Song, Wei, Li, Xueli, Li, Lingyu, Du, Zhonghua, Jia, Lin, Zhou, Lei, Li, Wei, Hoffman, Andrew R., Hu, Ji-Fan, Cui, Jiuwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central 11.12.2018; BMC
• Subjects: Breast cancer; breast neoplasms; Breast Neoplasms - metabolism; breasts; Chromatin; Circular RNA; CpG islands; CRISPR; CRISPR-Cas Systems; Demethylation; Deoxyribonucleic acid; DNA; DNA (Cytosine-5-)-Methyltransferase 1 - metabolism; DNA demethylation; DNA hypomethylation; DNA Methylation; DNMT1; DNMT1 protein; Epigenetics; ETS protein; Exons; FLI1; Gene expression; Gene Expression Regulation, Neoplastic; Hematology; Humans; Identification; immunohistochemistry; Immunoprecipitation; Invasiveness; Leukemia; Lymphoma; Metastases; Metastasis; Methyltransferase; methyltransferases; Mitochondrial DNA; Mixed Function Oxygenases - metabolism; Neoplasm Metastasis; oncogene proteins; precipitin tests; Proto-Oncogene Protein c-fli-1 - metabolism; Proto-Oncogene Proteins - metabolism; proto-oncogenes; Ribonucleic acid; RNA; Solid tumors; Stem cells; TET1; transcription factors; Tumors; viruses; DNMT1; DNA methylation; Circular RNA; TET1; Tumor; Breast cancer; FLI1

Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. However, little is known about the mechanisms underlying the activation of this proto-oncogene in tumors. Immuno...