Advances and gaps in SARS-CoV-2 infection models

• Published in: PLoS pathogens Vol. 18; no. 1; p. e1010161
• Main Authors: Muñoz-Fontela, César, Widerspick, Lina, Albrecht, Randy A., Beer, Martin, Carroll, Miles W., de Wit, Emmie, Diamond, Michael S., Dowling, William E., Funnell, Simon G. P., García-Sastre, Adolfo, Gerhards, Nora M., de Jong, Rineke, Munster, Vincent J., Neyts, Johan, Perlman, Stanley, Reed, Douglas S., Richt, Juergen A., Riveros-Balta, Ximena, Roy, Chad J., Salguero, Francisco J., Schotsaert, Michael, Schwartz, Lauren M., Seder, Robert A., Segalés, Joaquim, Vasan, Seshadri S., Henao-Restrepo, Ana María, Barouch, Dan H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2022; Public Library of Science (PLoS)
• Subjects: Age Factors; Analysis; Animal diseases; Animal experimentation; Animal models; Animals; Asymptomatic; Biology and life sciences; Comorbidity; Coronaviruses; COVID-19; COVID-19 - etiology; COVID-19 - prevention & control; COVID-19 - therapy; COVID-19 vaccines; COVID-19 Vaccines - adverse effects; COVID-19 Vaccines - immunology; Demographic variables; Disease Models, Animal; Disease transmission; Humans; Infections; Laboratories; Medical research; Medicine and health sciences; Methods; Mutation; Pathogenesis; Proteins; Research and Analysis Methods; Review; SARS-CoV-2 - immunology; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Vaccines; Viral diseases; Virulence; Virulence (Microbiology); Viruses; Syria

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates o...