Phylogenetic analysis of migration, differentiation, and class switching in B cells

• Published in: PLoS computational biology Vol. 18; no. 4; p. e1009885
• Main Authors: Hoehn, Kenneth B., Pybus, Oliver G., Kleinstein, Steven H.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2022; Public Library of Science (PLoS)
• Subjects: Algorithms; Allergies; Antibodies; B cells; B-cell receptor; B-Lymphocytes; Biological research; Biology and Life Sciences; Biology, Experimental; Cell adhesion & migration; Cell Differentiation - genetics; Class switching; Computer and Information Sciences; Differentiation (biology); Evolution; Food allergies; Food hypersensitivity; Genetic aspects; HIV; HIV Infections; Human immunodeficiency virus; Humans; Hypotheses; Immunoglobulin Class Switching; Information processing; Isotypes; Lymphocytes B; Medicine and Health Sciences; Mutation; Phylogenetics; Phylogeny; Phylogeography; Physical Sciences; Physiological aspects; Receptors, Antigen, B-Cell - genetics; Research and Analysis Methods; Statistical analysis; Statistics; Switching; United States

B cells undergo rapid mutation and selection for antibody binding affinity when producing antibodies capable of neutralizing pathogens. This evolutionary process can be intermixed with migration between tissues, differentiation between cellular subsets, and switching between functional isotypes. B c...