DeepCRISPR: optimized CRISPR guide RNA design by deep learning - Chuai, Guohui; Ma, Hanhui; Yan, Jifang; Chen, Ming; Hong, Nanfang; Xue, Dongyu; Zhou, Chi; Zhu, Chenyu; Chen, Ke; Duan, Bin; Gu, Feng; Qu, Sheng; et al. (Genome Biology, 2018)
Keywords: Cell Line; Cell Line, Tumor; Clustered Regularly Interspaced Short Palindromic Repeats - genetics; Computational Biology - methods; Computer applications; Computer Simulation; CRISPR; CRISPR system; CRISPR-Cas Systems - genetics; Data processing; Deep learning; Deoxyribonucleic acid; Design; DNA; Epigenetics; Gene knockout; genome; Genomes; HCT116 Cells; HEK293 Cells; HeLa Cells; HL-60 Cells; Humans; Hypotheses; Learning algorithms; Machine Learning; Method; Off-targets; On-targets; prediction; Ribonucleic acid; RNA; RNA Editing - genetics; RNA, Guide, CRISPR-Cas Systems - genetics; Target recognition; Deep learning; On-targets; CRISPR system; Off-targets; Gene knockout