Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion

• Published in: PLoS pathogens Vol. 13; no. 6; p. e1006429
• Main Authors: Jiang, Lingyan, Feng, Lu, Yang, Bin, Zhang, Wenwen, Wang, Peisheng, Jiang, Xiaohan, Wang, Lei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.06.2017; Public Library of Science (PLoS)
• Subjects: Animals; Bacterial Proteins - genetics; Biology and Life Sciences; Biotechnology; Blotting, Western; Cellular signal transduction; Chromatin Immunoprecipitation; Disease Models, Animal; E coli; Education; Electrophoretic Mobility Shift Assay; Female; Gene deletion; Gene expression; Gene Expression Regulation, Bacterial - genetics; Genes; Genomics; Infections; Intestine; Laboratories; Medicine and Health Sciences; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Oral infection; Oxygen; Oxygen - metabolism; Oxygen tension; Pathogenicity; Pathogens; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Salmonella; Salmonella Infections - genetics; Salmonella typhimurium; Science; Signal transduction; Signal Transduction - physiology; Tension; Transcription; Transcription (Genetics); Transduction; Virulence; Virulence (Microbiology); Virulence - genetics

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major intestinal pathogen of both humans and animals. Salmonella pathogenicity island 1 (SPI-1)-encoded virulence genes are required for S. Typhimurium invasion. While oxygen (O2) limitation is an important signal for SPI-1 induction unde...