Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes

• Published in: PLoS pathogens Vol. 14; no. 6; p. e1007145
• Main Authors: McDonald, Lindsay, Cayla, Mathieu, Ivens, Alasdair, Mony, Binny M, MacGregor, Paula, Silvester, Eleanor, McWilliam, Kirsty, Matthews, Keith R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2018; Public Library of Science (PLoS)
• Subjects: African trypanosomiasis; Animals; Biology and Life Sciences; Blood - parasitology; Cell cycle; Cell Differentiation; Cellular signal transduction; Combinatorial analysis; Complementation; Differentiation; Ectopic expression; Gene expression; Gene silencing; Genetic aspects; Genome; Genomes; Genomics; Immunology; Infections; Kinases; Medicine and Health Sciences; Mice; Molecular chains; Muscidae; Mutants; Nonlinear analysis; Parasites; Pathogens; Phosphatase; Phosphorylation; Protein kinase; Proteins; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Quorum Sensing; Ribonucleic acid; RNA; RNA-binding protein; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Science education; Signal processing; Signal Transduction; Signaling; Trypanosoma; Trypanosoma brucei; Trypanosoma brucei brucei - genetics; Trypanosoma brucei brucei - metabolism; Trypanosomiasis, African - parasitology; Vector-borne diseases; United Kingdom > UK; Scotland; Edinburgh Scotland

Trypanosoma brucei, the agents of African trypanosomiasis, undergo density-dependent differentiation in the mammalian bloodstream to prepare for transmission by tsetse flies. This involves the generation of cell-cycle arrested, quiescent, stumpy forms from proliferative slender forms. The signalling...