Epstein-Barr Virus-Encoded LMP1 Interacts with FGD4 to Activate Cdc42 and Thereby Promote Migration of Nasopharyngeal Carcinoma Cells

• Published in: PLoS pathogens Vol. 8; no. 5; p. e1002690
• Main Authors: Liu, Hao-Ping, Chen, Chia-Chun, Wu, Chih-Ching, Huang, Yi-Chuan, Liu, Shu-Chen, Liang, Ying, Chang, Kai-Ping, Chang, Yu-Sun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2012; Public Library of Science (PLoS)
• Subjects: Actin Cytoskeleton - physiology; Baits; Biology; Cancer; Cancer cells; Carcinoma; cdc42 GTP-Binding Protein - biosynthesis; cdc42 GTP-Binding Protein - genetics; cdc42 GTP-Binding Protein - metabolism; Cell adhesion & migration; Cell growth; Cell Line, Tumor; Cell migration; Cell morphology; Cell Movement; Cytoskeleton; Development and progression; Epstein-Barr virus; Epstein-Barr Virus Infections - metabolism; Experiments; Guanine Nucleotide Exchange Factors - metabolism; Health aspects; HEK293 Cells; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - metabolism; Humans; Interleukin-1alpha - metabolism; Kinases; Ligands; Lymphoma; Membrane proteins; Microfilament Proteins - deficiency; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Motility; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - pathology; Physiological aspects; Plasmids; Proteins; rac1 GTP-Binding Protein - metabolism; rhoA GTP-Binding Protein - metabolism; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha - metabolism; Viral Matrix Proteins - metabolism; Virulence (Microbiology); Taiwan

Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), a human malignancy notorious for its highly metastatic nature. Among EBV-encoded genes, latent membrane protein 1 (LMP1) is expressed in most NPC tissues and exerts oncogenicity by engaging multiple signaling pathway...