Innate immune surveillance of the circulation: A review on the removal of circulating virions from the bloodstream

• Published in: PLoS pathogens Vol. 18; no. 5; p. e1010474
• Main Authors: Ander, Stephanie E., Li, Frances S., Carpentier, Kathryn S., Morrison, Thomas E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2022; Public Library of Science (PLoS)
• Subjects: Adenoviruses; Antibodies; Antibody response; Bacteria; Biology and Life Sciences; Blood circulation; Chikungunya virus; Ecological effects; Evaluation; Gene therapy; Hepatitis; Host-virus relationships; Immune clearance; Immune response; Immunity, Innate; Immunosurveillance; Liver; Medicine and Health Sciences; Observations; Pathogenesis; Pathogens; Research and Analysis Methods; Reticuloendothelial system; Review; Spleen; Streptococcus infections; Viral infections; Virion; Virions; Virus research; Viruses; Viruses - genetics; United States

Many viruses utilize the lymphohematogenous route for dissemination; however, they may not freely use this highway unchecked. The reticuloendothelial system (RES) is an innate defense system that surveys circulating blood, recognizing and capturing viral particles. Examination of the literature show...