NCOA2 promotes lytic reactivation of Kaposi’s sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA

• Published in: PLoS pathogens Vol. 15; no. 11; p. e1008160
• Main Authors: Wei, Xiaoqin, Bai, Lei, Dong, Lianghui, Liu, Huimei, Xing, Peidong, Zhou, Zhiyao, Wu, Shuwen, Lan, Ke
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2019; Public Library of Science (PLoS)
• Subjects: Activation; B cells; Biology and Life Sciences; Carcinogenesis; Gene expression; Gene Expression Regulation, Viral; Genes; Health aspects; HEK293 Cells; HeLa Cells; Herpesviridae Infections - genetics; Herpesviridae Infections - metabolism; Herpesviridae Infections - virology; Herpesvirus 8, Human - physiology; Humans; Immediate-Early Proteins - genetics; Immediate-Early Proteins - metabolism; Immunoglobulins; Infection; Infections; Kaposis sarcoma; Laboratories; Latency; Life sciences; Ligases; Mass spectrometry; MDM2 protein; Medicine and Health Sciences; Novels; Nuclear Receptor Coactivator 2 - genetics; Nuclear Receptor Coactivator 2 - metabolism; Positive feedback; Proteasomes; Protein binding; Proteins; Replication; Research and analysis methods; Sarcoma; Scientific imaging; Stability; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription; Tumorigenesis; Ubiquitin; Ubiquitin-protein ligase; Viral infections; Virology; Virus Activation; Virus Latency; Virus Replication; China

Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Give...