EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production - Luo, Zhen; Su, Rui; Wang, Wenbiao; Liang, Yicong; Zeng, Xiaofeng; Shereen, Muhammad Adnan; Bashir, Nadia; Zhang, Qi; Zhao, Ling; Wu, Kailang; Liu, Yingle; Wu, Jianguo (PLoS pathogens, 2019)
Keywords: Animals; Antibodies; Apoptosis; Astrocytes; Astrocytes - metabolism; Astrocytes - pathology; Astrocytes - virology; Biology and Life Sciences; Body weight; Body weight loss; Brain; Brain - metabolism; Brain - pathology; Brain - virology; Caspase-3; Cell survival; Central nervous system; Cerebral cortex; Child, Preschool; Cleavage; Coxsackievirus infections; Death; Development and progression; Disease; Disruption; Encephalitis; Enterovirus A, Human - isolation & purification; Enterovirus Infections - complications; Enterovirus Infections - virology; Enteroviruses; Epidemics; Female; Foot and mouth disease; Funding; Hand-foot-and-mouth disease; Health aspects; House mouse; Humans; Immune system; Infant; Infants; Infection; Infections; Inflammation; Integrity; Interleukin 6; Interleukin-6 - metabolism; Interleukins; Laboratories; Life sciences; Male; Medicine and Health Sciences; Meningitis; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Microscopy; Neomycin; Nervous system diseases; Neurodegeneration; Neurodegenerative Diseases - epidemiology; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - virology; Neurological diseases; Novels; Pathogenesis; Proteins; Research and Analysis Methods; Rodents; Signaling; Software; Survival; TLR7 protein; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - metabolism; Toll-like receptors; Virology; Viruses; Weight loss; Japan; China