Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

• Published in: PLoS computational biology Vol. 17; no. 10; p. e1009468
• Main Authors: Zarnitsyna, Veronika I., Akondy, Rama S., Ahmed, Hasan, McGuire, Donald J., Zarnitsyn, Vladimir G., Moore, Mia, Johnson, Philip L. F., Ahmed, Rafi, Li, Kelvin W., Hellerstein, Marc K., Antia, Rustom
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell culture; Cell death; Cell division; Computational Biology; Deuterium; Differential equations; Epidemic models; Epidemiology; Fever; Health aspects; Humans; Immunologic Memory - immunology; Immunological memory; Immunology; Infections; Labeling; Low level; Lymphocytes; Lymphocytes T; Medicine and Health Sciences; Memory cells; Models, Immunological; Mortality; Pathogens; Physical Sciences; Physiological aspects; Population; Prevention; Research and Analysis Methods; T cells; Vaccination; Vaccines; Vector-borne diseases; Viral infections; Viral vaccines; Viruses; Yellow fever; Yellow Fever Vaccine - immunology; Yellow fever virus - immunology; United States

Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effects differential equations framework to analyze da...