Determinants for the Development of Visceral Leishmaniasis Disease

• Published in: PLoS pathogens Vol. 9; no. 1; p. e1003053
• Main Authors: McCall, Laura-Isobel, Zhang, Wen-Wei, Matlashewski, Greg
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2013; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Development and progression; Disease Vectors; Genetic aspects; Host-Pathogen Interactions; Humans; Infections; Insect bites; Kala-azar; Leishmania donovani - genetics; Leishmania donovani - immunology; Leishmania donovani - pathogenicity; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Cutaneous - parasitology; Leishmaniasis, Cutaneous - pathology; Leishmaniasis, Visceral - immunology; Leishmaniasis, Visceral - parasitology; Leishmaniasis, Visceral - pathology; Macrophages - parasitology; Medical research; Medicine; Neglected Diseases; Parasites; Physiological aspects; Proteins; Psychodidae - parasitology; Review; Rodents; Tropical diseases; Vector-borne diseases; Viral genetics; Virulence (Microbiology); Canada

Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral infections. Among the most important questions in Leishmania research is why some species like L. donovani infect visceral o...